Mortality associated with drug-induced liver injury (DILI)

Letter of support for drug-induced liver injury (DILI) biomarker

The objectives of DILI WP3 were to qualify one or a set of new biomarkers with respect to: an early or earlier diagnosis of DILI as compared to current diagnostic rules the ability to predict DILI outcome, with particular emphasis on severe DILI/acute liver failure the prognosis and monitoring of progression and regression of DILI the differentiation between patients who incur true drug-induced...

The Challenge of Drug-Induced Liver Injury (DILI) / Challenges and Management of Liver Cirrhosis. Preface.

Recurrent drug-induced liver injury (DILI) with ciprofloxacin and amoxicillin/clavulanic.

Ciprofloxacin and amoxicillin/clavulanic are two widely used antibiotics due to their high efficacy and few side effects. While the percentage of hepatotoxicity of these antibiotics is low, their frequent use has led to a progressive increase in the number of cases. Both antibiotics have been associated with a wide variety of hepatotoxic reactions, from a slight rise of transaminases to fulmina...

The rediscovery of HepG2 cells for prediction of drug induced liver injury (DILI)

In the past HepG2 cells have been considered to show only little similarity to primary human hepatocytes (Godoy et al., 2013; Hewitt et al., 2007). However, recently it has become clear that the phenotype of HepG2 cells strongly depends on culture conditions. In a recent study, Ramaiahgari et al. (2014) cultivated HepG2 cells in spheroids. In this culture system the cells stopped proliferation ...

Genetic variations in drug-induced liver injury (DILI): resolving the puzzle

Despite stringent requirements for drug development imposed by regulatory agencies, drug-induced liver injury (DILI) is an increasing health problem and a significant cause for failure to approve drugs, market withdrawal of commercialized medications, and adoption of regulatory measures. The pathogenesis is yet undefined, though the rare occurrence of idiosyncratic DILI (1/100,000–1/10,000) and...